10 results
diagnosis differential algorithm classification oncology aplastic approach cobalamin disorders elevatedmcv gastroenterology gastrointestinal hemophagocytic hlh iron lymphohistiocytosis macrocytic macrocytosis mds morphologic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... (>100 fL) • B12 ... #MCV #Classification ... #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
chronic kidney disease ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... differential #diagnosis #causes ... #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Reticulocytes, MCV ... • B12/Folate ... of Chronic Disease ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... • Dietary Deficiency ... and Folate Deficiency ... #Hematology
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... tests Test for celiac ... disease with serology ... change medical management ... #Evaluation #workup
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... PT, aPTT(liver disease ... anemia (vegan, ... - Bone marrow evaluation ... #Workup #hematology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation ... #diagnosis #management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... , GATA2 deficiency ... , CTLA4 deficiency ... #oncology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Adult-onset Still disease ... Cellular immune deficiency ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... Workup: • Complete ... Syndromes #diagnosis #hematology
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