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diagnosis hematology treatment product reactions aortic cerebritis cns coagulation dic differential disorders dissection disseminated erythematosus hemophagocytic hemophilia hlh intravascular lupus
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... plateletcount), peripheral blood ... PT, aPTT(liver disease ... - Bone marrow evaluation ... #Workup #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... screening for disease ... normal in mild cases ... Avoid meds that ... #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... • Severe Liver Disease ... Treat primary cause ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... • Autoimmune diseases ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... thrombosis and/or blood-brain ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management
Aortic Dissection Pearls Aortic dissection is caused by a tear in the tunica intima, the innermost layer
dissection is caused ... Evaluation: 1. ... • Aortic valve disease ... ~60 • Control blood ... Dissection #diagnosis #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... cause of transfusion ... coagulopathy & ↑bleeding ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... cause of transfusion ... coagulopathy & ↑bleeding ... Transfusions #diagnosis #management ... #hematology #reactions
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