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hematology management symptoms erythematosus lupus oncology sle syndrome workup activation algorithm arteritis arthritis autoantibodies behcet chronic classification cll gca giantcell
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Fever is the main clinical ... with leukopenia, anemia ... 5000 to 10,000 ng/mL ... Activation #Syndrome #Diagnosis ... #Rheumatology
Gout (Gouty Arthritis) - MSK Radiology Imaging Findings: • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
mass and NO prior signs ... ON THE X-RAY! ... Differential diagnosis ... diffuse chondral disease ... #msk #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome Systemic ... association • M > F Clinical ... ) Differential Diagnosis ... #management #signs ... #symptoms #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... Sneddon-Wilkinson disease ... #Monoclonal #Differential ... #Diagnosis #Oncology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... signs/sx of inflammation ... very remarkable w/differential ... complaints- anemia ... them, but urgent rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Diagnosis Framework ... Diagnosis: • Systemic ... purpura: Strong sign ... #Diagnosis #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Orange or Hep C Clinical ... Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia
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