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differential management hematology neurology oncology symptoms weakness algorithm bronchiectasis causes cll copper gout gravis hypomagnesemia hyponatremia leukemia lymphocytic magnesium mds
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Diagnosis - ... test - Cogan sign ... - Peek sign ... inhibition - Chronic ... #Gravis #diagnosis
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Demyelinating Disease (MS ... Guillain-Barre syndrome ... , Myasthenia Gravis ... : Acid maltase deficiency ... #differential #diagnosis
Risk Factors and Signs of Copper Deficiency Risk Factors: • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
of Copper Deficiency ... bowel disease, Chronic ... diarrhoea, Short bowel syndrome ... dental fixatives, Treatment ... #diagnosis #signs
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hematology for workup ... Acute hemolysis, deficiency ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... endocrine: Vitamin B12 deficiency ... Postsynaptic: Myasthenia ... Lack of UMN/LMN signs ... dystrophies Work
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... #workup #oncology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
• Mounier-Kuhn syndrome ... Nasal polyps and signs ... parenchyma Diagnosis ... α1-antitrypsin deficiency ... mycobacteria Treatment
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... • Copper deficiency ... Workup: • Complete ... #diagnosis #hematology
Hyponatremia - Diagnosis and Treatment Hyponatremia is usually caused by the inability to excrete water normally.
Hyponatremia - Diagnosis ... Then, ask 3 questions ... to work through ... correction of chronic ... demyelination syndrome
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
Gout - Diagnosis ... sex • Metabolic syndrome ... double contour sign ... Dual-energy CT → MSU ... +Radiographic signs
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