7 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
(TLS) and Treatment ... 8.0 mg/dL • Potassium ... age and sex) • Cardiac ... #TLS #diagnosis ... #management #oncology
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
≥ 8 mg/dL • Potassium ... of the above Treatment ... abnormalities • Cardiac ... #diagnosis #management ... #oncology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
AKI, acute limb ischemia ... leukapheresis - TLS ... lethargy, hematuria, cardiac ... with tetany or cardiac ... #TLS #diagnosis
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
- Differential Diagnosis ... iniury, Compartment syndrome ... HIV, Influenza, TSS ... decreased renal renal ischemia ... Monitor potassium
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Acidosis, Cell Lysis (TLS ... /crush injury, ischemia ... tourniquet / IVF line draw ... line, stabilizes cardiac ... #potassium #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... HIV, Influenza, TSS ... perfusion → renal ischemia ... Monitor potassium ... #Differential #Diagnosis
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
and Differential Diagnosis ... Hypercoagulable (APLAS) Microbiology ... Cholesterol emboli syndrome ... Early embolic/ischemic ... hematuria, + RF Treatment