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rheumatology management dermatology sle erythematosus differential photo skinrash syndrome workup activation arthritis causes cerebritis chronic classification cll cns comparison cryoglobulinemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... (SLE) Clinical ... permeability Diagnosis ... #cerebritis #diagnosis ... #management #treatment
Vesiculobullous Skin Rash - Differential Diagnosis Algorithm Vesicles Fragile/EasiIy Ruptured - Intraepidermal blisters, possibly crusts/erosions - Inflammatory
- Differential Diagnosis ... Algorithm Vesicles ... • Herpes simplex ... • Bullous systemic ... lupus erythematous
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... #Summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... Fever is the main clinical ... lupus erythematosus ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... months to years) Systemic ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Differential Diagnosis ... Malignancy (e.g. hematologic ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... deposit of immune complexes ... Syndrome: • Clinical ... Labs/Diagnosis: ... lupus erythematosus
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... Orange or Hep C Clinical ... ’s CLL Scoring system ... microglobulin Treatment ... workup #oncology #hematology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
reconstituted immune system ... noncompliance • Clinical ... initiation Clinical ... leukoencephalopathy (PML ... Virus • Herpes simplex
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
affected joint • Systemic ... lupus erythematosus ... Polyarthritis: • Complete ... (to support a diagnosis ... ANA and RF (if clinical
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