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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient have glomerular ... dysmorphic RBCs in urine ... #Syndrome #Comparison ... #Algorithm #Nephrology ... #Diagnosis
Spectrum of Glomerular Diseases
Nephrotic - Mechanism:
 • Injury to podocytes
 • Changed architecture: Scanning. Deposition of
Diseases Nephrotic ... other elements Nephritic ... differential #spectrum #diagnosis ... #nephrology #nephritic ... #nephrotic #comparison
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
- Nephritic and ... Nephrotic Syndromes ... RBC casts in urine ... #Proteinuria #Nephrology ... #Diagnosis
Summary of characteristic abnormalities of selected glomerular diseases
Light Microscopy (LM) - Immunofluorescence Microscopy (IM) - Electron
EM) Haematuria/nephritis ... Haemolytic-uraemic syndrome Nephrotic ... #diseases #nephrology ... #pathology #comparison ... #table #diagnosis
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
arbitrarily defined as urine ... clusters because nephritic ... urine sediment ... #nephrotic #syndrome ... #nephrology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
disease 24-hour urine ... Spot PC (protein ... testing #workup #diagnosis ... glomerulonephritis #nephrotic ... #nephritic #nephrology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
disease 1) 24-hour urine ... Spot PC (protein ... #workup #diagnosis ... initial #testing #nephrology ... #nephrotic #nephritis
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... formation along glomerular ... glomerulopathy, radiation nephritis ... Glomerulonephritis #MPGN #nephrology ... #diagnosis #renal
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Antibiotics (Bactrim, PCN ... tourniquet / IVF line draw ... lysis) ± Urine ... Management #Treatment #potassium ... #nephrology #K