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diagnosis differential hematology symptoms erythematosus lupus management oncology systemic testing algorithm arthritis behcet cardiology causes chronic classification cll effusion extraarticular
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... lesions Abdominal pain ... (20%) Renal disease ... ) Blood (75%): Anemia ... erythematosus #signs
Causes of Pericardial Effusion - Differential Diagnosis Infectious: • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus • Bacterial: Mycobacterium
Non-Infectious: • Rheumatologic ... : SLE, Rheumatoid ... Mediterranean Fever • Vasculitis ... Primary: Lymphoma, Leukemia ... • Metabolic: Uremia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... ): SS, SC, SE, Sβ ... cardiac valve, vasculitis ... Diagnosis #Algorithm #workup ... #hematology #testing
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
infections, bone pain ... extramedullary disease ... , fever, joint pain ... - infiltrates (anemia ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Physical Exam/Signs ... cells can indicate disease ... • Neutropenia, anemia ... #diagnosis #workup
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract: abdominal pain ... purpura: strong sign ... , testes -> pain ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... tears, Ischemia, Leukemia ... Nonsurgical abdominal pain ... diagnosis #management #signs ... #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... lymphopenia, low PLT • Anemia ... Hodgkin lymphoma and leukemia ... Erythematosus #Diagnosis #Rheumatology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... reticularis Blood: Anemia ... interstitial lung disease ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... purpura: Strong sign ... tract: Abdominal pain ... involvement, abdominal pain ... Differential #Diagnosis #Rheumatology
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