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anemia coagulation hemolysis management workup algorithm atlas bleeding bruising disorders disseminated elevatedmcv extravascular hemolytic hemostasis macrocytic macrocytosis morphology platelet product
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... coagulation (DIC ... • Intrinsic RBC ... #Causes #differential ... #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... Myelodysplastic Syndromes ... Deficiency - Abnormal ... #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Liver diseases ... #Atlas #key #diagnosis ... #differential # ... hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
MAHA: TTP, HUS, DIC ... Defects, Drugs, Liver ... - Peripheral Blood ... Smear ↑ abnormal ... #Diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
ABO incompatible blood ... • Severe Liver ... INR < 2.3 - APTT ... hydration • RBC ... #management #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... plateletcount), peripheral blood ... : INR/PT, aPTT(liver ... #Diagnosis #Causes ... #Workup #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... von Willebrand syndrome ... , disseminated intravascular ... discern these causes ... #Diagnosis #Hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... reflection of intravascular ... of Peripheral blood ... count and differential ... #Workup #Hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... pain, dark urine, DIC ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
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