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abnormal activation algorithm blood coagulation common cvid dermatology hemolysis hypogammaglobulinemia immunodeficiency immunology intravascular macrophage mas mcv nonpalpable palpable product prolonged
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... thrombocytopenic purpura ... #Causes #differential ... #diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Renal Disease, Liver ... #MCV #Classification ... #Causes #Hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... : • Liver disease ... #Anemia #Differential ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... anemia - Splenomegaly ... deficiency • Liver ... Diagnosis #hematology ... #rheumatology #
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... associated with systemic ... #diagnosis #differential ... #hematology #coagulation
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Thrombocytopenic Purpura ... hallmark for the disease ... performed PT, PTT ... WBC count and differential ... #Workup #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... with leukopenia, anemia ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
in recipient (e.g ... Causes purpura & ... eruptions, diarrhea, liver ... #Transfusions #diagnosis ... #management #hematology
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