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liver algorithm blood product reactions acidosis aclf ascites chemistry chronic cirrhosis drug druginduced elevation failure hepatitis hepatorenal hrs hrsaki hrsckd
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... symptoms of liver disease ... Idiosyncratic #differential ... #Diagnosis #Management ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Diagnosis Algorithm ... for alternative causes ... Alcohol-related liver disease ... dechallenge • Acute ... #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
underlying liver disease ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology ... #gastroenterology ... #management #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... Vascular Causes ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... obstruction, HELLP Syndrome ... Diagnosis #Causes ... #hepatology
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
Hepatorenal Syndrome ... (HRS) - Diagnostic ... nephrotoxics (e.g ... structural kidney injury ... #HRSNAKI #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... • Gilbert's syndrome ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Ascites - Diagnostic Approach and Differential Diagnosis The most common causes: cirrhosis, malignancy and heart failure. Approx
most common causes ... more than one cause ... (e.g. cirrhosis ... of underlying disease ... #Diagnosis #hepatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... presentations and disease ... - Compartment syndrome ... #Diagnosis #causes ... #typea #typeb #classification
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Acute Hemolytic ... Transfusion Related Acute ... Lung Injury (TRALI ... #Transfusion #diagnosis ... #management #hematology
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