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oncology algorithm lymphoma thrombocytopenia ascites chronic comparison disorders enlarged erythematosus extravascular gap globulin hemolysis hemolytic intravascular lupus lymphocytic macrocytic macrocytosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... Myelodysplastic syndrome ... Diagnosis #Causes ... #hematology #secondary
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
involved) • No leukemic ... translocation • Types: Classification ... • Other hematologic ... #differential # ... hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... • Lymphoma • Leukemia ... vera, essential thrombocytosis ... • Sickle Cell ... #Causes #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Diagnosis: • ... cells can indicate disease ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Myelodysplastic Syndromes ... #Macrocytosis #elevatedMCV ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... basophilia, and thrombocytosis ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... . lupus, CLL, lymphoma ... . sickle cell disease ... #differential # ... diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
) Classification ... Lymphoma Workup ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... changes), high MCV anemia ... not required in all ... #Diagnosis #Causes ... #Workup #hematology
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