11 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... intravascular coagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
80-100 fL) • Bleeding ... (e.g. ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Thrombocytopenia • Prolonged ... • Severe Liver ... Disease: - Impaired ... INR < 2.3 - APTT ... #management #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... : INR/PT, aPTT(liver ... disease), HBsAg ... #Diagnosis #Causes ... #Workup #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
) • aPTT is prolonged ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Diagnosis Framework ... von Willebrand syndrome ... the PT remains prolonged ... discern these causes ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
purpura to mucosal bleeding ... thrombocytopenia • Liver ... Fibrin degradation products ... #Diagnosis #Management ... #Hematology #Rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Paradoxical spontaneous bleeding ... Antiphospholipid syndrome ... skin necrosis • DIC ... #rheumatology # ... hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... eruptions, diarrhea, liver ... coagulopathy & ↑bleeding ... #Transfusions #diagnosis ... #management #hematology