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management coagulation abnormal blood bruising intravascular prolonged activation algorithm anemia atlas dermatology disorders extravascular hemolysis hemolytic hemostasis key macrophage mas
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Severe Liver ... Disease: - Impaired ... #DIC #Disseminated ... #Coagulation #diagnosis ... #management #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Thrombocytopenia ... Iatrogenic) • Liver ... Deficiency • Disseminated ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... Diagnosis and Workup ... : INR/PT, aPTT(liver ... #Diagnosis #Causes ... #Workup #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... • Reduced liver ... #Causes #diagnosis ... hematology #coagulation
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): - Disseminated ... intravascular coagulation (DIC ... microangiopathy: Thrombotic thrombocytopenic ... #differential # ... diagnosis #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... Early liver disease ... #Causes #diagnosis ... #differential # ... hematology #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... fever • Drug reactions ... #Diagnosis #hematology ... #rheumatology #
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
, Liver diseases ... , Bleeding gastric ... coagulopathy (DIC ... #differential # ... hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
von Willebrand syndrome ... PTT suggests liver ... failure, disseminated ... discern these causes ... #Diagnosis #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
purpura to mucosal bleeding ... • Liver function ... degradation products ... #Diagnosis #Management ... #Hematology #Rheumatology
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