ecg qtc syndrome acltear hematology disease differential classification causes rheumatology diagnosis workup disorders bruising pancytopenia bleeding autoimmune

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Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
• Decreased Production
•

Causes of Bleeding ... / Bruising - Differential ... Rare • Drugs (e.g ... #Bruising #Differential ... #Causes #Hematology

Pancytopenia - Workup and Differential Diagnosis Algorithm
Consumption Disorders
1. Autoimmune Mediated Pancytopenia
2. Splenic Sequestration
Peripheral Destruction

Pancytopenia - Workup ... and Differential ... Metastatic Disease ... #Workup #Differential ... #Hematology

Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
- Prior platelet count, family

- Differential ... Diagnosis and Workup ... ITP, unexplained pancytopenia ... Diagnosis #Causes ... #Workup #hematology

Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Diagnostic Framework ... Extravascular Causes ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology

Cryoglobulinemia Summary

Cryoglobulins:
• Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below

• They can cause ... Cryoglobulins Cause ... diseases: - 10% ... #types #classification ... #rheumatology #

Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in

Bleeding and Bruising ... Diagnosis Framework ... von Willebrand syndrome ... discern these causes ... Diagnosis #Hematology

SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and

Classification: ... permanent alopecia Differential ... rheumatologic diseases ... (e.g. thyroid disease ... #Rheumatology

Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
• 40-70 years with a modest female predominance

Cryofibrinogenemia:
• The precipitation of a

Paradoxical spontaneous bleeding ... associated with autoimmune ... Antiphospholipid syndrome ... #rheumatology # ... hematology

Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly

formed or don’t work ... Easy or unusual bruising ... Myeloproliferative Disease ... blood count with differential ... #diagnosis #hematology

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