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diagnosis algorithm hemolytic thrombocytopenia abnormal activation agglutinin aptt autoimmune coagulation cold disorders elevatedmcv elevation erythematosus extravascular hemolysis intravascular lactic lupus
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
- Differential ... Megakaryopoiesis • Aplastic Anemia ... Alloimmune • anti-HLA antibodies ... Non-lmmune: • HELLP Syndrome ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... (e.g. ... #MCV #Classification ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... - Drugs (Beta lactam ... #differential # ... diagnosis #hematology ... #anemia
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology ... #Differential # ... Diagnosis #Algorithm #causes
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Causes of Lactate ... presentations and disease ... of Circulatory System ... - Compartment syndrome ... 30mmHg) - Severe anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... function test, ANA (e.g ... anti-phospholipid antibodies ... changes), high MCV anemia ... #Workup #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(eg, systemic juvenile ... with leukopenia, anemia ... Triglycerides • ↑ Lactate ... Diagnosis #Management #Hematology ... #Rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Cold Agglutinin Syndrome ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... #hematology #diagnosis
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... associated with systemic ... #diagnosis #differential ... #hematology #coagulation
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