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diagnosis causes coagulation prolonged rheumatology bleeding bruising classification dermatology disorders elevatedmcv erythematosus lupus macrocytic macrocytosis macrophage management mas mcv naildisorders
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... associated with systemic ... #PT #aPTT #Prolonged ... Causes #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... • Reduced liver ... associated with systemic ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Diagnosis Algorithm ... Increased Requirement (e.g ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Volume (MCV) - Differential ... Diagnosis Algorithm ... Chronic Disease Normal ... Chronic Disease (e.g ... #Causes #Hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... halt nail growth (e.g ... discoloration) • Liver ... #Differential # ... Diagnosis #Algorithm
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Destruction • Abnormal ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... selected cases: INR/PT ... , aPTT(liver disease ... changes), high MCV anemia ... bypass), LFT (liver
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... with leukopenia, anemia ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... . hematologic) ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation
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