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diagnosis differential rheumatology erythematosus lupus sle symptoms systemic autoimmune bullous headaches infections inflammatory intermittent mimickers myopathies myopathy myositis neurology pemphigoid
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
: Subacute • Pattern ... to 50X ULN • Autoantibodies ... heliotrope, shawl sign ... : Subacute • Pattern ... differential #diagnosis #comparison
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... schistosomiasis • Pyemia ... usual diurnal pattern ... Brucellosis Faget's Sign ... with profound hemolysis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Erythematosus #Diagnosis #autoantibodies ... #signs #symptoms
Pemphigus Vulgaris vs Bullous Pemphigoid - Comparison Table Pemphigus Vulgaris • Epidemiology: Average age 40-60 • Time
Bullous Pemphigoid - Comparison ... ruptured • Nikolsky sign ... • Antibodies: Autoantibodies ... of tombstone" pattern ... Tense • Nikolsky sign
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: Fever ... ) Blood (75%): Anemia ... normochromic nomocytic or haemolytic ... erythematosus #signs
Headaches Overview - Primary vs Secondary Headaches What’s the Core Difference? • Primary headache = headache is
• Meningitis (fever ... N Neurological signs ... confusion, focal signs ... (>50 years) P Pattern ... Primary #Secondary #Comparison
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
papules and Gottron sign ... ) • Shawl sign ... Overlap Syndrome: Fever ... slow onset and pattern ... Mechanic's hands Autoantibodies
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