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diagnosis differential rheumatology erythematosus hematology lupus systemic symptoms workup algorithm chronic cll dermatology endocarditis infections infective intermittent leukemia lymphocytic marantic
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Erythematosus #Diagnosis #autoantibodies ... #signs #symptoms
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... genotypes): SS, SC, SE ... bartonella (oroya fever ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... ) General: Fever ... ) Blood (75%): Anemia ... Thrombocytopenia #Lupus #SLE ... erythematosus #signs
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... schistosomiasis • Pyemia ... Brucellosis Faget's Sign ... with profound hemolysis
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... - CTD (SLE) ... Associated - SLE ... mountain spotted fever
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
pathognomonic signs ... conditions: Autoimmune (SLE ... Clinical features: Fever ... Clinical features: Fever ... #Endocarditis #comparison
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... weight loss, and fever ... • Anti-Ro/SSA autoantibodies ... lymphopenia, low PLT • Anemia ... to: Arthritis, Fever
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Lymphadenopathy • Fevers ... Physical Exam/Signs ... • Neutropenia, anemia
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