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diagnosis differential nephrology algorithm causes renal management clinical pocus pharmacology ultrasound endocrinology pathophysiology kidney treatment table signs rheumatology symptoms workup
Limbic system Medial/rostral hypothalamus Lateral hypothalamus Hypothalamic neurosecretion ADH Autonomic centers Signal generator CRH Negative feedback Sympathetic nervous system Anterior pituitary ACTH Adrenal medulla Adrenal cortex #Cortisol #Epinephrine (norepinephrine) Response to signal
CRH Negative feedback ... pituitary ACTH Adrenal ... medulla Adrenal
Primary Adrenal Insufficiency: • ACTH stimulation test - Synthetic ACTH does not stimulate cortisol secretion because
Primary Adrenal ... dysfunctional adrenal ... Elevated, because feedback ... inhibition by adrenal ... injury to the adrenal
Regulation of GFR Physiologically, GFR is auto-regulated very precisely with changes in the mean arterial pressure (MAP)
neuro-hormonal feedback ... Tubuloglomerular feedback ... Neuro-hormonal feedback
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
sudden +++ positive feedback ... negative to positive feedback
Hyperkalemia: Diagnostic algorithm Decreased renal potassium excretion • Acute renal failure • Chronic renal failure • Drugs Increased
algorithm Decreased renal ... excretion • Acute renal ... • Congenital adrenal ... Addison's/congenital adrenal ... high: • Post-renal
Adrenal Crisis Do not confuse acute adrenal crisis with Addison disease. In 1855, Thomas Addison described a
Adrenal Crisis ... confuse acute adrenal ... syndrome of long-term adrenal ... contrast, an acute adrenal ... be a cause of adrenal
Feedback Loop: Prolactin (PRL) • PRL levels exhibit diurnal, menstrual, and age-related variation • TRH has
Feedback Loop: Prolactin
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Primary Adrenal ... Damage of the adrenal ... aldosterone Causes of Adrenal ... Tuberculosis: can cause adrenal ... melanoma Bilateral Adrenal
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte - Causes hyperkalemia? - Safe to
per @kidney_boy feedback
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing Common causes: • Renal parenchymal disease
Common causes: • Renal ... evaluate cause of renal ... h of infusion Adrenal ... CT scan, adrenal ... • Congenital adrenal
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