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diagnosis rheumatology differential classification ana antibodies antibody antineutrophil antinuclear aortitis cryofibrinogenemia cryoglobulinemia cryoglobulins dermatitis dermatology diseases erythema erythematosus glomerulonephritis lupus
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
antibodies) • Systemic ... drug-induced SLE) • Systemic ... - Anti-U1-RNP ANCA-Associated ... Vasculitis: • ... Renal-limited vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: ANCA Associated ... tract, and often causes ... Hydralazine-Induced ANCA-Associated ... Vasculitis: + MPO-ANCA ... differential #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
RPGN has three primary ... pathophysiologic causes ... Glomerulonephritis • With associated ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Kawasaki disease - Primary ... central nervous system ... small vessels - ANCA-associated ... disease - systemic ... Vessels #Diagnosis #Rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... Cryoglobulinemia (MIXED) • ANCA ... associated small ... - MPA • CTD Associated ... Differential #Diagnosis #hematology
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Non-Infectious Aortitis: • Vasculitides ... Nodosa (PAN), ANCA ... associated vasculitis ... Arthritis (RA), Systemic ... Differential #Diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
with GCA or as primary ... Rash, arthritis Primary ... : ANCA Associated ... tract, and often causes ... Differential #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... DDX: • ANCA (Antineutrophil ... disorder (e.g. systemic
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... vasculitis, rheumatoid ... the context of primary ... Malignancy Associated
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Primary (essential ... malignancies, vasculitis ... processes: • Systemic ... cryoglobulins • Negative causes ... #hematology
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