14 results
Who to test for BRCA 1/2?
Female Breast Cancer:
 • ≤ 45-50 years at diagnosis
 • Triple
Female Breast Cancer ... in this table ... factors in this table ... BRCA #testing #indications ... #oncology #Breast
Major Chemotherapy Toxicities - AntiNEOPlastic Man Mnemonic

Common Toxicities with Traditional Chemotherapeutic Medications 

Originally posted on pharmacologyweekly
Chemotherapeutic Medications ... SideEffects #Adverse #Pharmacology ... AntiNeoplastic #Man #Oncology ... #Table
Oral anti-hypertensives with relative fast onset of action (Hypertensive Emergency)

The key concern with oral antihypertensive agents
Emergency) The key concern ... you're up-titrating medications ... allow one dose of medication ... Emergency #Management #Pharmacology ... #Table #BloodPressure
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Nephron and their Functions ... Nephron #Segments #Function ... #Pathophysiology ... #Tubules #Table ... #Pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
has very minimal chance ... different than other medications ... check the kidney function ... very tolerable medication ... Renal #Dosing #Pharmacology
Checkpoint inhibitors and indications
Anti CTLA-4 antibody:
 • Ipilimumab: Malignant melanoma, Renal cell cancer
Anti-PD-1 antibody:
 • Nivolumab:
inhibitors and indications ... , Renal cell cancer ... , Gastric cancer ... Checkpoint #inhibitors #indications ... #oncology #pharmacology
Summary of meta-analysis of pharmacotherapy trials in BPD
https://www.cochrane.org/CD005652/BEHAV_psychological-therapies-borderline-personality-disorder
Meta-analyses of RCTs were undertaken for the following outcomes:
psychopathology, anger ... summarised in Tables ... EBM #Management #Pharmacology ... Personality #Disorder #Medications ... Effectiveness #Table
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... #Interactions #Table ... #Pharmacology
Pancreatitis management checklist 
Evaluation to guide etiology & management 
 - RUQ ultrasound 
 - Calcium
Evaluation to guide etiology ... level - Liver function ... - Review of medication ... limit them as able
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
thus effectively functions ... margin of safety in pharmacology ... the sublingual tablet ... Pharmacokinetics #Comparison #Table ... #Pharmacology #