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Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
overt cytoplasmic granules ... I see all of these ... promyelocytic #leukemia #APL ... #APML #Pathology ... #Hematology #Clinical
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
abundant cytoplasmic granules ... promyelocytic leukemia (APL ... decreased secondary granules ... In addition to APL ... #Clinical #Path
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 Antiphospholipid Syndrome (APS) APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
) APS is a rare ... Antiphospholipid antibodies (aPL ... at least: • 1 clinical ... 1 of the three aPLs ... presence of 1 clinical
Here are very large, immature myeloblasts with many nucleoli. A distincitve feature of these blasts is
of crystallized granules ... myelogenous leukemia (AML ... #Clinical #Path ... Rods #AuerRods #AML
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview: ALL ... , CML, AML, APML ... age • 75% of ALL ... Mature B-cell ALL ... distinctive primary granules
Algorithmic Approach to Acute Interstitial Nephritis When to suspect AIN? (not sensitive) • AKI, AKD, rapidly progressive
Algorithmic Approach ... tubular proteinuria, granular ... Nephritis #AIN #Algorithm
Examples of varying granular and granular/waxy mixed casts: A: coarse granular/broad-waxy (and surrounding white blood cells);
Examples of varying granular ... and granular/waxy ... /muddy brown granular ... #Granular #MuddyBrown ... Urine #Microscopy #Clinical
Granular & “Muddy Brown” Casts on Urine Microscopy A. Finely granular cast B. slightly coarser granular cast
Granular & “Muddy ... Finely granular ... slightly coarser granular ... #Granular #MuddyBrown ... Urine #Microscopy #Clinical
Waxy and granular casts - brightfield urine microscopy Dr. Telma Lemos @TELMALEMOS10 #Waxy #granular #casts #Urine #Microscopy #clinical
Waxy and granular ... TELMALEMOS10 #Waxy #granular ... Urine #Microscopy #clinical
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 Abnormal Lipid Profiles - Differential Diagnosis Algorithm Increased Cholesterol and Triglycerides - Genetic Causes
Differential Diagnosis Algorithm ... Causes • Apo-A1 ... • Familial LPL ... Deficiency • Apo-Cll ... Differential #Diagnosis #Algorithm
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