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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... #Hypereosinophilic ... HES #Hematology #eosinophilia ... #eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... attributable to eosinophilia ... confirmed tissue eosinophilia ... with blood eosinophilia ... Alert_Oriented3 #Hypereosinophilia
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Peripheral blood eosinophilia ... /hypereosinophilia ... specific symptoms • Eosinophilia ... 1,500 cells/µL • Hypereosinophilia
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Leukemia - Primary Hypereosinophilic ... Syndrome - Chronic Eosinophilic ... coyefish379 #Eosinophilia
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Eosinophilia - Differential ... Primary Eosinophilia ... : • Primary hypereosinophilic ... syndrome • Eosinophilic ... Secondary Eosinophilia
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Diagnosis of Pulmonary Eosinophilia ... Tropical pulmonary eosinophilia ... sting Others: • Eosinophilic ... chronic pulmonary eosinophilia ... , Hypereosinophilic
Categories of disease to consider for eosinophilic meningitis:
-Multicellular parasites (worms and flukes)
-Fungal: Cocci
-Atypical bacterial/mycobacterial: TB, syphilis,
to consider for eosinophilic ... Hypereosinophilic ... Medications #Diagnosis #Eosinophilic ... #Eosinophilia #
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Diseases • Acute Eosinophilic ... SOB • Chronic Eosinophilic ... fever, rhinitis • Eosinophilic ... , CV, renal • Hypereosinophilic
Secondary Causes of Esophageal Eosinophilia (EoE) - Differential Diagnosis
 • Gastroesophageal reflux disease
 • Eosinophilic gastrointestinal
of Esophageal Eosinophilia ... reflux disease • Eosinophilic ... Achalasia • Hypereosinophilic ... #esophagitis #Eosinophilic
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... TerrierBen #Eosinophils ... #hypereosinophilia