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diagnosis dermatology rash hemophagocytic hlh lymphohistiocytosis petechiae petechial apml causes differentiation dress erythematous hemeonc lesions leukostasis lysis nikolsky nonpalpable oncology
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... If fever is present ... but without a fever ... #Nikolsky #Febrile ... #Fever #Differential
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH Vesiculobullous rashes provoke significant angst in many physicians (Figure 5, page
Vesiculobullous Rashes - THE ALGORITHMIC ... vesiculobullous rash and a fever ... localized lesions and fever ... #Diagnosis #Dermatology ... Vesiculobullous #Rash #Algorithm
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... Diagnosis Algorithm ... Red Flags: • Fever ... Mucosal lesions • Severe ... medication Febrile
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... petechiae/purpura with fever ... petechiae/purpura with fever ... the patient is afebrile ... #Diagnosis #Dermatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Definition: • Severe ... Fever >38.5 2. ... Resolution > 15 days Differentials ... SinaiBmoreIMRes #DRESS #Syndrome ... #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... - 80% have fever ... Treatment: - If febrile ... TLS #diagnosis #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Pustular Skin Lesions - Differential Diagnosis Framework What are pustules? • Pustules < 5-10 mm + pus • Material
Skin Lesions - Differential ... SAPHO syndrome ( ... Pustules + Fever ... pustulosis • Febrile ... Sweet syndrome
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
consideration in febrile ... Characteristics: Persistent fever ... Persistent high fever ... Fever b. ... #Hematology #HemeOnc
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