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diagnosis ana antinuclear autoantibodies management associations clinical comparison differential endocarditis erythematosus infective lupus marantic msas myositis nbte noninfective patterns polychondritis
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Antibodies (MSAs ... , TIF1y, NXP2, Mi ... clinical #diagnosis #rheumatology ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA - Non-specific ... common in SLE, autoimmune ... #diagnosis #table ... #rheumatology # ... antibodies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... Positive ANA ≠ Autoimmune ... but often not specific ... ANA #patterns #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features that are specific ... Predisposing conditions: Autoimmune ... heart valves • MRI ... - Infectious Diseases ... Marantic #diagnosis #table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... hypofunction • Antibodies ... Anti-Ro/SSA ab (specific ... • Antinuclear antibodies ... Sjogrens #Syndrome #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cartilage in the body (Autoimmune ... Sarcoidosis • Behcet disease ... not sensitive or specific ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology
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