18 results
diagnosis differential classification management workup allergy ana antinuclear autoantibodies clinical comparison hematology hypersensitivity laboratory reactions testing types vasculitis abnormal aptt
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Antibodies (MSAs ... , TIF1y, NXP2, Mi ... clinical #diagnosis #rheumatology ... #table
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... but often not specific ... connective tissue disease ... • Rheumatic Diseases ... ANA #patterns #rheumatology
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
Tests for Celiac Disease ... patients with celiac disease ... Sensitivity for celiac disease ... value for celiac disease ... expensive #Celiac #Disease
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... and relapse No specific ... autoantibodies (antinuclear antibodies ... IgG4 #Related #Disease ... workup #treatment #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Specific inhibitors ... antiphospholipid antibodies ... antiphospholipid antibodies ... #differential #hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen - Allergen-specific ... lgE antibodies ... When the specific ... during hemolytic disease ... Diagnosis #Reactions #Table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... well as inner ear disease ... atherosclerotic disease ... most important diseases
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