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diagnosis differential classification management workup allergy antinuclear autoantibodies comparison hematology hypersensitivity laboratory reactions testing types vasculitis abnormal aptt arthritis associations
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Disease! ... but often not specific ... connective tissue disease ... • Rheumatic Diseases ... #rheumatology #diagnosis
Commonly Used Diagnostic Tests for Celiac Disease Tissue transglutaminase (tTG) IgA antibodies - Most reliable noninvasive test
Tests for Celiac Disease ... patients with celiac disease ... Sensitivity for celiac disease ... value for celiac disease ... expensive #Celiac #Disease
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... relapse No specific ... autoantibodies (antinuclear antibodies ... IgG4 #Related #Disease ... workup #treatment #rheumatology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
of Abnormal PT and ... Early liver disease ... antiphospholipid antibodies ... antiphospholipid antibodies ... #differential #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... well as inner ear disease ... atherosclerotic disease ... most important diseases
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen - Allergen-specific ... lgE antibodies ... When the specific ... during hemolytic disease ... Diagnosis #Reactions #Table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... types #allergy #table
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