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diagnosis management allergy ana autoantibodies classification hypersensitivity reactions workup arthritis associations comparison differential erythematosus igg4 laboratory lupus pathophysiology patterns phenotypes
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... ANA ≠ Autoimmune Disease ... but often not specific ... • Rheumatic Diseases ... #patterns #rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... connective tissue disease ... (TTG) - Celiac disease ... #Associations #diseases ... antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... with auto-immune diseases ... erythematosus #diagnosis #rheumatology ... #table #ANA
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen - Allergen-specific ... lgE antibodies ... When the specific ... during hemolytic disease ... Diagnosis #Reactions #Table
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... autoantibodies (antinuclear ... antibodies, rheumatoid ... IgG4 #Related #Disease ... workup #treatment #rheumatology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... #allergy #table
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
multisystemic disease ... associated with other diseases ... demyelinating disease ... peripheral Thyroid Disease ... Tracheobronchial disease
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Studies in Rheumatic Diseases ... Tests for All Types ... exclude inflammatory disease ... connective-tissue disease ... #Rheumatic #Disease
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
immunologically mediated diseases ... Sarcoidosis • Behcet disease ... not sensitive or specific ... to type II collagen ... Polychondritis #rheumatology
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