7 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... Anti-Synthetase Syndrome ... clinical #diagnosis #rheumatology ... #table
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... but often not specific ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... #patterns #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Associations ANA - Non-specific ... La) - Sjogren's syndrome ... #diagnosis #table ... #rheumatology # ... antibodies
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis #rheumatology ... #table #ANA
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Anti-Ro/SSA ab (specific ... ab • RF • Antinuclear ... antibodies ≥ 1: ... IV RTA, TYPE I ... #Rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... erythematosus (SLE) - Antinuclear ... double-stranded DNA antibodies ... which are more specific ... Tests for All Types
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
Sarcoidosis • Behcet disease ... not sensitive or specific ... Anti-Matrilin-1 Ab ○ Antibodies ... to type II collagen ... Polychondritis #rheumatology