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autoantibodies management allergy ana antinuclear arthritis associations classification clinical disease erythematosus hypersensitivity laboratory lupus msas myositis pathophysiology polychondritis reactions relapsing
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE antibodies ... When the specific ... during hemolytic disease ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and their Disease ... Associations ANA - Non-specific ... #diagnosis #table ... #rheumatology # ... antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... Anti-Ro/SSA ab (specific ... IV RTA, TYPE I ... RTA Diagnosis: ... Sjogrens #Syndrome #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... double-stranded DNA antibodies ... which are more specific ... Tests for All Types ... #testing #Rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
not sensitive or specific ... Anti-Matrilin-1 Ab ○ Antibodies ... to type II collagen ... Polychondritis #rheumatology ... #diagnosis #management
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