13 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... , Haemolytic disease ... #table #classification
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies ... When the specific ... during hemolytic disease ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Associations ANA - Non-specific ... #diagnosis #table ... #rheumatology # ... antibodies
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Pager Summary Type ... determines blood type ... Blood Product Types ... #Transfusions #diagnosis ... #management #hematology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... Anti-Ro/SSA ab (specific ... IV RTA, TYPE I ... RTA Diagnosis: ... Sjogrens #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... Associated - ANCA specific ... , drug reactions ... C-ANCA) pattern: antibodies ... #rheumatology #
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... double-stranded DNA antibodies ... which are more specific ... Tests for All Types ... #testing #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... , drug reactions ... oligoclonal bands • MRI ... Pauci Immune (ANCA specific ... #Rheumatology