14 results
Hypercalcemia Workup and Differential Diagnosis Framework
1) Determine whether PTH-dependent
2) Assess for other hormonal causes
3) Assess for
Hypercalcemia Workup ... Determine whether PTH-dependent ... #Workup #Differential ... Diagnosis #algorithm #endocrinology ... #calcium
Parathyroid Hormone (PTH) Effect in Calcium and Phosphorus
Calcium - Net Effect Hypercalcemia:
   ↑ intestinal
Parathyroid Hormone (PTH ... - Net Effect Hypercalcemia ... Parathyroid #Hormone #PTH ... #Phosphorus #pathophysiology ... #endocrinology
Pathophysiology of Tumor Lysis Syndrome (TLS)
Tumor Cell Lysis
-> Release of DNA
 • Purines -> Hypoxanthine /
Pathophysiology ... of Tumor Lysis Syndrome ... (TLS) Tumor Cell ... • Hyperkalemia ... #TLS #Pathophysiology
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Hypocalcemia - Diagnosis ... - Calcium Sequestration ... - DiGeorge Syndrome ... Signaling #Hypocalcemia ... Diagnosis #Management #endocrinology
Tumor lysis syndrome refers to the constellation of metabolic disturbances that occurs when large numbers of
Tumor lysis syndrome ... hyperuricemia, #hyperkalemia ... acutekidneyinjury #Pathophysiology ... #Presentation #TLS ... #Workup #tumorlysissyndome
Hypocalcemia Workup - Differential Diagnosis Algorithm
 • Low Magnesium, High Magnesium - Functional Hypoparathyroidism
 • High
Hypocalcemia Workup ... Phosphate, Low PTH ... Phosphate, High PTH ... metastases, Hungry bone syndrome ... #Workup #Differential
Hypercalcemia Evaluation
1) Clinical clues
 - Is the patient symptomatic?
 - Family history?
 - Have you done
Hypercalcemia Evaluation ... 2) PTH - Frankly ... #diagnosis #endocrinology ... #calcium #elevated ... #evaluation #workup
Hypocalcemia - Differential Diagnosis Algorithm - Low and High Phosphate
LOW PHOSPHATE
 - Low/NormaI PTH
Hypocalcemia - Differential ... Phenytoin, Nephrotic Syndrome ... Activating Mutation in Calcium ... Poisoning #Hypocalcemia ... Algorithm #Phosphate #endocrinology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... leukapheresis - TLS ... : • Pathophysiology ... hydration - Hyperkalemia ... #TLS #diagnosis
Causes of Hypocalcemia - Differential Diagnosis
Decreased calcium absorption
 • Vitamin D deficiency
    -
Causes of Hypocalcemia ... Diagnosis Decreased calcium ... Malabsorption Syndromes ... Increased calcium ... Diagnosis #Causes #endocrinology