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diagnosis causes differential management hypocalcemia rhabdomyolysis signs treatment 21hydroxylasedeficiency alkaline alp bulimianervosa complications encephalopathy genetics hematology hepatology high hyophosphatasia insufficiency
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
Pseudohyperparathyroidism, Renal ... histoplasmosis) • Milk (calcium ... )-alkali syndrome ... differential #diagnosis #calcium ... #high #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... Hirsutism & acne • Infertility ... #21HydroxylaseDeficiency #21OHD ... #pathophysiology ... #genetics #endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... Lithium use • Calcium-sensing ... , adrenal, prostate ... • Milk-alkali syndrome ... #Causes #endocrinology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... : • Pathophysiology ... hydration - Hyperkalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... : • Triad of symptoms ... urine • Other symptoms ... or compartment syndrome ... potassium and calcium
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium ... hyperphosphatemia, hypercalcemia ... , and possibly renal ... patients) and/or hypercalcuria
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... potassium and calcium ... Dialysis for severe hyperkalemia
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
Adrenal Insufficiency ... ketoconazole, etomidate) Symptoms ... Hyperkalemia is ... hypophysitis, Sheehan's syndrome ... Diagnosis #Management #Endocrinology
Causes of Hypocalcemia by Clinical Cause Acute illness: pancreatitis, tumor lysis, severe illness - Secondary hyperparathyroidism from
low circulating calcium ... Genetic defects in calcium-sensing ... Malabsorption syndrome ... gland removal Renal ... Differential #Diagnosis #Endocrinology
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 Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
collection with EDTA Pathophysiology ... ALP -> PPi and Calcium ... mineralization Symptoms ... : - Renal failure ... Hyperlipidemia - Hypercalcemia
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