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diagnosis management causes differential nephrology oncology rhabdomyolysis bulimianervosa complications deposition disease emergencies gitelman hematology hemeonc hypokalemia leukostasis lysis oncologic pseudogout
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
of Tumor Lysis Syndrome ... (TLS) and Treatment ... 4.6 mg/dL • Calcium ... Treatment of TLS ... • Hypocalcemia
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... leukapheresis - TLS ... : • Pathophysiology ... • Treatment: ... #TLS #diagnosis
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... HIV, Influenza, TSS ... Hyperphosphatemia • Hypocalcemia ... /Late - Hypercalcemia ... potassium and calcium
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... HIV, Influenza, TSS ... Dermatomyositis) AKI - Pathophysiology ... potassium and calcium
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Pseudogout Summary - Calcium ... ) Pathophysiology ... precipitates with calcium ... Acute Pseudogout: Treatment ... Crowned Dens Syndrome
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... low Ca - q8 h TLS ... plasmapheresis Hypercalcemia ... malignancy: - Calcium ... /dL → treat - Calcium
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
• Unexplained hypokalemia ... Hypocalciuria (spot urine, calcium-creatinine ... Rhabdomyolysis Treatment ... nephrology #management #pathophysiology ... #Hypokalemia
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
• Boerhaave syndrome ... > Amenorrhea & Infertility ... Calcium, VitD) and ... ) • Overall: hypokalemia ... Complications #pathophysiology
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