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diagnosis causes differential symptoms growthhormone pituitary adrenal bulimianervosa complications cushings excess feedbackloop glftap hirsutism hypercortisolism hyperfunction hypertension indications macroadenoma masseffects
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Feedback Loop: Growth Hormone ... (GH) Growth Hormone ... activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
Growth Hormone Excess ... Carpal Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology ... #pathophysiology
Weight Gain / Obesity - Differential Diagnosis Algorithm Decreased Expenditure: • Sedentary Lifestyle • Smoking Cessation
Differential Diagnosis Algorithm ... Hypothyroid • Cushing's ... • GH Deficiency ... Iatrogenic: • Drugs/Hormones ... #endocrinology
Cushing Syndrome Testing Algorithm INDICATIONS FOR TESTING: • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension) Testing:
Cushing Syndrome ... Testing Algorithm ... syndrome (central ... Adrenocorticotropic Hormone ... #algorithm #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
common), growth hormone ... following order; GH ... Signs / Symptoms ... #SideEffects #endocrinology ... mnemonic #GLFTAP #pathophysiology
Hirsutism & Virilization - Differential Diagnosis Algorithm ADRENAL EXCESS Ovarian • Polycystic Ovarian Syndrome • Hyperthecosis • Tumor Adrenal
Differential Diagnosis Algorithm ... Hyperplasia • Cushing's ... Low Serum Hormone ... Differential #Diagnosis #Algorithm ... #endocrinology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Endrocrine • Cushing's ... Disease • GH ... Differential #Diagnosis #Algorithm ... #endocrinology
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Cushing's Syndrome ... melanocyte stimulating hormone ... #Syndrome #Hypercortisolism ... #Diagnosis #signs ... #symptoms #endocrinology
Causes of Secondary Hypertension - Workup and Differential Diagnosis Approach (when evaluation should be done): 1. Severe or
hypertension and signs ... renal bruit or signs ... of hormonal excess ... Vasculitis • Endocrinologic ... Hypercalcemia, Cushing's
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
• Boerhaave syndrome ... of nutrients, hormonal ... VitD) and lowered hormone ... Complications #pathophysiology ... #diagnosis #signs
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