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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
underlying hematologic disorders ... • Diagnosis and ... #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia Syndrome ... (HES) - Diagnosis ... - Immunologic disorders ... #diagnosis #hematology ... #differential #
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... #Disorders #Algorithm ... #Differential # ... diagnosis #hematology ... #eosinophilia
NAACP mnemonic for the major causes of Eosinophilia 
N = Neoplasia (CML, Hodgkins lymphoma) 
A =
NAACP mnemonic for ... Connective tissue disorders ... #NAACP #Differential ... #Causes #Diagnosis ... #Mnemonic
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
- Differential ... Diagnosis Bugs: ... Hypereosinophilic Syndrome ... #Differential # ... #hematology
Causes of Enuresis - Differential Diagnosis Algorithm
Primary Nocturnal Enuresis (Urinary Control Never Achieved)
 • Delayed Maturation
of Enuresis - Differential ... Diagnosis Algorithm ... Enuresis: • Pediatric ... Non-neurogenic (Hinman Syndrome ... #Diagnosis #Algorithm
Causes of Developmental Delay - Differential Diagnosis Algorithm
Isolated Domain Delay - Reduced Respiratory Drive:
 • Cognitive
Developmental Delay - Differential ... Diagnosis Algorithm ... Landau-Kleffner Syndrome ... #Diagnosis #Algorithm ... #Causes #Peds #Pediatrics
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Erythema Nodosum - Mnemonic ... Sarcoidosis or Lofgren's syndrome ... Erythema #Nodosum #Mnemonic ... #Causes #Differential ... #Diagnosis #Dermatology
Secondary Causes of Esophageal Eosinophilia (EoE) - Differential Diagnosis
 • Gastroesophageal reflux disease
 • Eosinophilic gastrointestinal
(EoE) - Differential ... Diagnosis • Gastroesophageal ... • Autoimmune disorders ... #Differential # ... Diagnosis #Secondary
Causes of Sudden Unexpected Death in Infancy (SUDI) - Differential Diagnosis Algorithm
Congenital Anomaly / Disorder:
 •
Infancy (SUDI) - Differential ... Diagnosis Algorithm ... • Metabolic Disorders ... Sudden Infant Death Syndrome ... #Causes #Peds #Pediatrics