12 results
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Like in this case ... - parvovirus, HIV ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... initiation • Differential ... Renal Failure Treatment ... • Supportive Care ... diagnosis #management #hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
during motion and ... Arthritis: • Acute ... e.g., congenital hip ... #Pain #MSK #rheumatology ... approach #workup #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Pain - Arthritis Differential ... spine, shoulders, hips ... #pain #Differential ... #Diagnosis #MSK ... #rheumatology #
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Responsive to Treatment ... Treated Like Acute ... Amy Chung, MD, MSc ... pathophysiology #Hematology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Fever/Chills/Joint ... Reactive Syndrome - Acute ... #diagnosis #msk ... #physicalexam
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Leg Pain - Differential ... Herpes zoster - HIV ... Immobilization) • Acute ... lower #extremity #msk ... #physicalexam
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
are dysfunctional ... Agent Orange or Hep ... microglobulin Treatment ... ’s lymphoma or acute ... workup #oncology #hematology
Extreme Patellofemoral Joint Instability (PFJI)

In this video you can see an extreme rare case of bilateral
Patellofemoral Joint ... ranging from frank acute ... hip abductor weakness ... Clinical #Video #PhysicalExam ... Orthopedics #Knee #msk
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... before beginning treatment ... Join the resistance ... cardiac output - Acute ... peritonitis - Acute