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Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... #Failure #Cirrhosis ... #Hepatology #gastroenterology ... #management #diagnosis
Indications for Albumin for Management of Cirrhosis
 • Large volume paracentesis (>5 liter) - 8g per
for Albumin for Management ... of Cirrhosis ... ascites removed • Acute ... #Cirrhosis #treatment ... #hepatology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
granules which are ... during an allergic reaction ... translocation • Acute ... Irradiation • Cirrhosis ... Diagnosis #causes #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
subclinical disease to acute ... liver failure ... hepatocellular pattern of liver ... #Diagnosis #Management ... #Hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
CIRRHOSIS - ... - Care focuses ... disease management ... Cholangitis #diagnosis #management ... #summary #Hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... headache, malaise) → Acute ... Support - Critical care ... #Pregnancy #hepatology ... obgyn #diagnosis #management
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
or fibrosis • Cirrhosis ... > 3 mg/dL) or acute ... liver failure ... #Indications #management ... #hepatology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
All patients who are ... Patients with cirrhosis ... and hematologic ... algorithm #diagnosis #management ... #hepatology #gastroenterology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Mixed - Check Acute ... NT) - If both are ... hepatitis: < 1 • Cirrhosis ... : > 1 • Acute ... #differential #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Vascular Causes of Acute ... NT) - If both are ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology