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diagnosis oncology treatment arthritis disease mds myelodysplastic adultonset apml approach chronic differential differentiation hemophagocytic hlh joint laboratory leukemia lymphocytic lymphohistiocytosis
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
) Rare inflammatory ... Must rule out other ... NSAIDs, steroids (acutely ... #rheumatology # ... diagnosis #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
large numbers and are ... • Richter’s Syndrome ... ’s lymphoma or acute ... Leukemia #diagnosis #workup ... #oncology #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... transformation to acute ... Conservative/supportive care ... Allogeneic stem cell ... #treatment #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of ... formed or don’t work ... anemia DDX: Rule Out ... Workup: • Complete ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... • Supportive Care ... APML #diagnosis #management ... #hematology #oncology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
Chronicity: • Acute ... Send for cell count ... Like in this case ... Joint #Pain #MSK #rheumatology ... #approach #workup
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... presents as an acute ... Low or absent NK cell ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... synovial fluid • Gout ... urate crystals (gout ... Screening Tests for Acute ... diagnosis #testing #Rheumatology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Diagnosis and Management ... presents with an acute ... chair, getting out ... PMR #Diagnosis #Management ... #Rheumatology
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