33 results
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
each of the above photos ... Dacrocytes are found ... metaplasia, pernicious anemia ... some hemolytic anemias ... Clinical #Path #BloodSmear
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
Two target cells are ... seen in the left photo ... present in the left photo ... with hemolytic anemias ... Clinical #Path #BloodSmear
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
In the right photo ... seen in hemolytic anemias ... microangiopathic hemolytic anemia ... is mechanical trauma ... Clinical #Path #BloodSmear
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Reactive: • Anemia ... blood loss (Fe deficiency ... rheumatologic, trauma ... Thrombocytosis #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Index < 2: • Anemia ... deficiencies: Iron deficiency ... Acute blood loss: Trauma ... , G6PD deficiency ... #differential #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Thrombocytosis - Differential ... Post-op surgery • Trauma ... malignancy • Iron deficiency ... anemia #Thrombocytosis ... #Differential #
Altered Mental Status - Differential Diagnosis
 • Neurologic: Stroke, Cerebral hypoxia, Cerebral hemorrhage, Seizure, Trauma, TBI,
Mental Status - Differential ... hemorrhage, Seizure, Trauma ... Electrolyte disturbance, Uremia ... Hypercarbia, Vitamin deficiency ... #Status #AMS #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
• Mechanical Trauma ... Microangiopathic hemolytic anemia ... lactam antibiotics are ... G6PD deficiency) ... Extravascular #Causes #differential
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Spoon-shaped • Iron deficiency ... anemia Onycholysis ... endocarditis • Trauma ... renal failure • Uremia ... #dermatology #Differential
Sickle cells
These photos show sickle cells on peripheral blood smears. In the left photo target cells
In the left photo ... target cells are ... no significant anemia ... sickle unless they are ... Clinical #Path #BloodSmear