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diagnosis hematology causes algorithm oncology hemolytic syndrome systemic disease disorders generalized hemophagocytic hlh lymphohistiocytosis nonpalpable pruritus rheumatology table workup activation
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... lymphoproliferative disorder Secondary ... • Symptoms of anemia ... younger pts) Differential ... #hematology #diagnosis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... (AIHA) - Differential ... hemoglobinuria) • Cold Agglutinin ... #AIHA #Differential ... Diagnosis #Table #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Hyperuricemia - Differential ... • Starvation Secondary ... - Hemolytic Anemia ... High purine diet Secondary ... Hyperuricemia #Differential
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Volume (MCV) - Differential ... Hypersplenism • Secondary ... #Differential # ... Algorithm #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
- Differential ... Thalassemia • ACD ... Non-hemolytic: ACD ... MCV #Algorithm #Differential ... #Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Diagnosis Secondary ... malignancies • Anemia ... Diagnosis #Causes #hematology ... #secondary
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... ARUPLabs #Hemolytic #Anemia ... #Differential #
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Iron deficiency anemia ... renal failure • Uremia ... NailDisorders #Systemic #Secondary ... #dermatology #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... . primary cold agglutin ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Volume (MCV) - Differential ... Secondary to Inflammation ... #elevatedMCV #Differential ... Algorithm #Causes #Hematology
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