31 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... predispose to other orthopedic ... common sites: hip ... #differential #diagnosis ... #causes #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Workup History ... pylori test (GI symptoms ... candidate) - Bone ... #Causes #Workup ... #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Bone and joint ... Diagnosis: ... • A clinical diagnosis ... Rule out other causes ... #Rheumatology #
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Causes of Knee Effusions ... - Differential Diagnosis ... Fever/Chills/Joint ... - Aneurysmal bone ... #Effusions #causes
Bone Deformity / Limp - Differential Diagnosis Algorithm 
Infection
 • Septic Arthritis
 • Cortical Hypertrophy
 •
Bone Deformity / ... JointHip Dysplasia ... Legg-Calve-Perthes Disease Knee ... Syndrome (Chondromalacia ... #Algorithm #Orthopedics
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... Like in this case ... - parvovirus, HIV ... #rheumatology # ... approach #workup
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... e.g., congenital hip ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #diagnosis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Drug induced - Bone ... Kasabach-Merritt syndrome ... Ig A vasculitis/HSP ... #hematology #rheumatology
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... etc) - Viral: HIV ... folate def - Bone ... antiphospholipid syndrome ... #Framework #hematology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
phenomenon (20%) Joints ... Aseptic necrosis of hip ... Demyelinating syndromes ... erythematosus #signs #symptoms ... #diagnosis #rheumatology