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CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
CNS Infection in ... HIV / AIDS - Differential ... CNS Opportunistic ... Infections in HIV ... #CNS #Infections
Stroke Mimics - Differential Diagnosis - MINT Mnemonic
 • Metabolic: Hyper-glycemia, Hypoglycemia, Wernicke's encephalopathy, Mitochondrial Encephalopathy
- Differential Diagnosis ... Hypercarbia • Infectious ... : Bell's palsy ( ... HSV), Vestibular ... neuronitis, CNS
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
and infects the CNS ... cells in the CNS ... Diagnosis: MRI ... disorder #dementia #AIDS ... #Neurology
Mycoses

HISTOPLASMOSIS
• Inhalation of conidia → Yeast → travel to lymph nodes → spread in body
• Bird
Pulmonary 3) Abdominal ... yeast • At risk: AIDS ... especially the CNS ... MC: CNS CSF: • ... osteoarticular, pulmonary, ocular
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
/AIDS patients ... be present: • AIDS ... pleural effusions, CNS ... skin lesions, ocular ... Zoster flare, ocular
Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
Lung Infections ... Diagnosis Framework ... Lymphadenopathy, CNS ... lymphadenopathy, • Abdominal ... #HIV #AIDS #pulmonary
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... affects the skin, neurologic ... multiplex • GI tract: Abdominal ... gut involvement, abdominal ... chorioretinitis, CNS
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... bouts of HTN Diagnostic ... Pleocytosis > 100 cells ... simplex virus, HIV ... #management #neurology
Summary of Oncologic Emergencies

Neutropenic fever:
- Fever + ANC < 500 → start cefepime ± vancomycin (if
CT abdomen if abdominal ... pain; full infectious ... ) - Symptoms: CNS ... ) - Symptoms: CNS ... Oncology #HemeOnc #Diagnosis