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hematology management oncology syndrome workup causes chronic cll leukemia lymphocytic abscess agglutinin algorithm aortoenteric aplastic apml b12 bandemia biliary bullous
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... Diagnosis Algorithm ... hepatomegaly • Labs: anemia ... platelets, persistent WBC ... #hematology #WBC
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #WBC #CBC #hematology ... #pathophysiology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... Pathophysiology ... Signs and Symptoms ... • Jaundice (later ... bile ducts Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... pylori test (GI symptoms ... changes), high MCV anemia ... disease), HBsAg/anti-HBc
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... blasts and high WBC ... • Lab values: WBC ... proliferation rate ... Syndrome #TLS #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... • Improve the symptoms ... #diagnosis #management
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
Management Summary Pathophysiology ... epidermis from dermis Clinical ... Signs/Symptoms/ ... IM Residency @CMC_IM ... #Management #dermatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... if high risk if WBC ... : >3 symptoms, or ... initiation • Differential ... QD until normal WBC
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... immunophenotype Clinical ... Vmphocytosis on routine CBC ... marrow failure with anemia ... #hemeonc #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... anemia • Cold ... Blood smear - RBC ... younger pts) Differential ... #hematology #diagnosis
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