25 results
Pathophysiology of Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar Syndrome (HHS)
Absolute Insulin deficit:
 - Type I DM:
Pathophysiology ... Hyperosmolar Syndrome (HHS ... Polydipsia #dka #hhs ... #pathophysiology ... #comparison #endocrinology
Mechanism of Action for Common Diabetes Medications

 • SGLT2i (Dapagliflozin)
 • TZD (Pioglitazone)
 • Biguanides (Metformin)
Action for Common Diabetes ... sarahthelyon #Diabetes ... #Medications #pharmacology ... #pathophysiology ... #endocrinology
Comparison of anti-diabetic or anti-hyperglycemic agents

There are numerous anti-hyperglycemic agents available to manage Type 2 diabetes.
Comparison of anti-diabetic ... manage Type 2 diabetes ... of medications has ... #pharmacology #pharmacotherapy ... #endocrinology
Pathyophysiology - hyperglycemic crises in patients with diabetes 
Key signs/symptoms of HHS/DKA:
Both: Polyuria, polydipsia, weight loss,
Pathyophysiology ... patients with diabetes ... signs/symptoms of HHS ... Pathophys #EM #IM ... #Endo #DKA #HHS
Estimating the Total Daily Dose (TDD) of Insulin: Weight-Based Dosing
TDD in units of insulin = N
: Weight-Based Dosing ... #TDD #Insulin #dosing ... Weight #Based #pharmacology ... #endocrinology ... #diabetes #DM2
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
Normal and Renal Dosing ... Inhibitors #Renal #Dosing ... #Pharmacology # ... Management #Diabetes ... #DM2 #Endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
to treat Type 2 Diabetes ... GLP1 #Agonists #Pharmacology ... #Dosing #Diabetes ... #DM2 #Endocrinology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... ensure patient has ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology ... #diabetes
Anaphylaxis: Treatments (Acute)
Additional Info:
 • IV steroids may be considered for prevention of late phase reactions.
prevention of late ... minimum of 4-6 hrs ... treatment) 1:1000 IM ... Treatments #Management #pathophysiology
Insulin Degludec (Tresiba) vs Insulin Glargine (Lantus, Basaglar, or Toujeo)

Insulin degludec (Tresiba) is an ultra-long acting
Basaglar, Toujeo) has ... do require BID dosing ... Glargine #Comparison #Pharmacology ... #DEVOTE #Diabetes