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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... #book-info #Nephron ... #Pathophysiology ... #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Diuretic Sites of Action ... Adenosine #Nephron ... #Pathophysiology ... #nephrology #pharmacology
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Injury - Sites of Action ... Along the Nephron ... AcuteKidneyInjury #AKI #Nephrology ... #Pathophysiology ... #Pharmacology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Vomiting, NGT suction ... intake, Diuretics (late ... Bartter Syndrome, Gitelman ... Diagnosis #Algorithm #Nephrology ... #Causes
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Bartter - Gitelman ... glomerular filtration rate ... extracellular anion ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... organic acids and bases ... tubule (DCT) - Active ... Segments #Function #Pathophysiology ... Tubules #Table #Pharmacology
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
, Intermediate Action ... Blockade, Fast Action ... Vaughan #Williams #Pharmacology ... Classification #Classes ... #pathophysiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... intracellular calcium causes ... Decreased heart rate ... #Pathophysiology
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... , Intermediate Action ... Antiarrhythmics #Pharmacology ... Classification #Classes ... #pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Vomiting, NGT suction ... intake, Diuretics (late ... Bartter Syndrome, Gitelman ... Diagnosis #Algorithm #Nephrology ... #Causes