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differential algorithm workup activation aplastic common cvid fever hemeonc hemophagocytic hlh hypogammaglobulinemia immunodeficiency immunology infectiousdiseases lymphohistiocytosis macrophage mas oncology rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diagnosis Congenital ... Diseases: • GATA2 ... deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Differential Diagnosis ... HLH syndrome 5. ... Acquired Aplastic Anemia ... Metastatic Disease ... #Algorithm #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
and Differential Diagnosis ... HLH syndrome 5 ... Acquired Aplastic Anemia ... Metastatic Disease ... #Algorithm #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... Constitutional Syndromes ... • Peripheral Pancytopenia ... #oncology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... highly inflammatory disease ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
autoimmune hemolytic anemia ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
region Viral Syndromes ... ; dengue shock syndrome ... capillary leak syndrome ... Infections: • Leptospirosis ... No hemolytic anemia
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... ▪ Autoimmune diseases ... - Cytopenias (anemia ... #Management #Hematology
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