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hepatology differential ascites injury workup abnormal management pbc primary rheumatology acute aion albumin alkaline alp anteriorischemicopticneuropathy cholangitis dermatology dili druginduced
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Infiltrative • Cirrhosis ... Duct Stone • Biliary ... • Others #LFTs ... #Algorithm #Causes
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... quadrant discomfort Signs ... Liver biopsy findings ... #Cirrhosis #Diagnosis ... #Algorithm #hepatology
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
’ algorithm • ... thin smear • Signs ... Liver biopsy • ... values supporting hematologic ... UnknownOrigin #workup #diagnosis
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... significant portal HTN Signs ... sarcoidosis) • Liver ... pregnancy • Primary biliary ... #causes #hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
congenital - Primary biliary ... Nonalcoholic fatty liver ... 14 percent) #Diagnosis ... #Differential #Hepatology ... #Cirrhosis #Causes
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 Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Non-Malignant • Fatty Liver ... Cholangitis • Primary Biliary ... Cirrhosis #Hepatomegaly ... #Algorithm #Causes ... #Hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Congenital, Others, Cirrhosis ... - CBD stone, Biliary ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... - Hepatic: • Cirrhosis ... disease • Acute liver ... failure • Primary biliary ... #Algorithm #Hepatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
Diagnosis of ascites ... protein ≤ 2.5 g/dL: Cirrhosis ... syndrome, Massive liver ... syndrome SAAG < 1.1: Biliary ... #algorithm
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... /Liver failure ... PBC Signs and ... or higher • Liver ... #workup #hepatology
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