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aspergillus betadglucan biomarkers differential diseases emergencies eosinophilia eosinophilic galactomannan hemeonc infections infectiousdiseases lung management mycoses oncologic pulmonary rheumatology urticaria
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
trigger - Direct skin ... symptoms - Headache, fever ... Disorientation, vertigo Diagnostic ... #diagnosis #rheumatology ... #comparison #table
Approach to Eosinophilic Lung Diseases • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
loss; CV, CNS, skin ... Infectious (Variable) - Fungal ... , parasites; Travel ... #differential #diagnosis ... #comparison #table
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
infection (IFI) in hematologic ... concurrent admin of mold-active ... post-2010 almost never ... Galactomannan #diagnosis ... #comparison
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
conidia → Yeast → travel ... respiratory symptoms • Fever ... osteomyelitis or skin ... that exists as a mold ... Mouth, throat, skin
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
> 4 days → add fungal ... syndrome): - Hematologic ... replacement Cord ... ± tocilizumab; call ... #HemeOnc #Diagnosis
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